Publications

Li,Z., Meng, Z., Lu, J., Chen, F.M., Wong, W.T., Tse, G., Zheng, C., Keung ,W.*,Tse, K., Li, RA.*, Jiang, L., Yao, X., TRPV6 protects ER stress-induced apoptosis viaATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes, J Mol Cell Cardiol, 2018Jul;120:1-11, doi: 10.1016/j.yjmcc.2018.05.008, Epub 2018 May 16.

Geng,L., Kong, C.W., Wong, A.O., Shum, A.M., Chow, M.Z., Che, H., Zhang, C., Yau,K.L., Chan, C.W., Keung, W.*, Li, R.A*, Probing flecainide blockof INa usinghuman pluripotent stem cell-derived ventricular cardiomyocytesadapted to automated patch-clamping and 2Dmonolayers, Toxicol Lett, 2018May 21;294:61-72, doi: 10.1016/j.toxlet.2018.05.006, [Epub ahead of print]

Li RA*, Keung W*, Cashman TJ, Backeris PC, Johnson BV,Bardot ES, Wong AOT, Chan PKW, Chan CWY, Costa KD. Bioengineering an electro-mechanically functionalminiature ventricular heart chamber from human pluripotent stem cellsBiomaterials, 2018May;163:116-127, doi: 10.1016/j.biomaterials.2018.02.024, Epub 2018 Feb 10.

LuJ, Boheler KR, Jiang L, Chan CW, Tse WW, Keung W*, Poon EN, Li RA*, YaoX, Polycystin-2 Plays an EssentialRolein Glucose Starvation-Induced Autophagy in Human Embryonic StemCell-DerivedCardiomyocytes, Stem Cells, 2018 Apr;36(4):501-513,doi: 10.1002/stem.2764, Epub 2018 Jan 3.

KongCW, Geng L, Li RA*, High-ContentElectrophysiologicalAnalysis of Human Pluripotent Stem Cell-DerivedCardiomyocytes (hPSC-CMs), MethodsMol Biol. 2018;1722:185-194, doi: 10.1007/978-1-4939-7553-2_12.

YafeiLi, Yaming Zhang, Weiping Wang*, Phototriggered targeting of nanocarriers fordrug delivery, Nano Research, 2018, in revision (invited review)

Fu,KS, Lehtinen, ML, Leung, CY, Lian, X., Xu, J., Keung, W., Geng, L., Kolstad,TR., Thams, S., Wong, AO, Wong, N., Bylund, K., Zhou, C., He, X., Jin, S-B.,Clarke, J., Landahl, U., Li, RA.*, Louch, W.E., Chien, KR, Human ISL1+ Ventricular ProgenitorsSelf-Assemble into an In Vivo Functional Heart Patch and Preserve CardiacFunction after Infarction, Molecular Therapy, doi:10.1016/j.ymthe.2018.02.012.

ChanPKW, Geng L, Gao Y, Keung W*, Li RA*, AAV-mediated conversion of human pluripotent stemcell-derived pacemaker, Biochem Biophys Res Commun, 2017 Dec9;494(1-2):346-351, doi: 10.1016/j.bbrc.2017.10.023, Epub 2017 Oct 6.

LeeEK, Tran DD, Keung W*, Chan P, Wong G, Chan CW, Costa KD, Li RA*, KhineM, Machine Learning of Human Pluripotent Stem Cell-DerivedEngineered Cardiac Tissue Contractility for Automated Drug Classification, StemCell Reports, 2017 Nov 14;9(5):1560-1572, doi: 10.1016/j.stemcr.2017.09.008,Epub 2017 Oct 12.

LuJ, Lee YK, Ran X, Lai WH, Li RA*, Keung W*, Tse K, Tse HF, Yao X, An abnormal TRPV4-related cytosolic Ca2+ rise in responseto uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytesfrom dilated cardiomyopathy patients, Biochim Biophys Acta, 2017Nov;1863(11):2964-2972, doi: 10.1016/j.bbadis.2017.07.021, Epub 2017 Jul 25.

SunY, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA*, FuJD, A Singular Role of IK1 Promoting the Development ofCardiac Automaticity during Cardiomyocyte Differentiation by IK1 -InducedActivation of Pacemaker Current, Stem Cell Rev, 2017Oct;13(5):631-643, doi: 10.1007/s12015-017-9745-1.

TseG, Liu T, Li G, Keung W*, Yeo JM, Fiona Chan YW, Yan BP, Chan YS, Wong SH, LiRA*, Zhao J, Wu WKK, Wong WT, Effects of pharmacological gap junction and sodiumchannel blockade on S1S2 restitution properties in Langendorff-perfused mousehearts, Oncotarget, 2017 Jul 28;8(49):85341-85352, doi:10.18632/oncotarget.19675, eCollection 2017 Oct 17.

KongCW, Chen S, Geng L, Shum AM, Sun D, Li RA*, Increasing the physical size and nucleation status ofhuman pluripotent stem cell-derived ventricular cardiomyocytes by cell fusion,Stem Cell Res, 2017 Mar;19:76-81, doi: 10.1016/j.scr.2017.01.003, Epub 2017 Jan6.

TseG, Chan YW, Keung W*, Yan BP, Electrophysiological mechanisms of long and short QTsyndromes, Int J Cardiol Heart Vasc, 2017 Mar; 14: 8–13, doi:10.1016/j.ijcha.2016.11.006.

TseG, Liu T, Li KH, Laxton V, Wong AO, Chan YW, Keung W*, Chan CW, Li RA*, Tachycardia-bradycardia syndrome: Electrophysiologicalmechanisms and future therapeutic approaches (Review),  Int JMol Med, 2017 Mar;39(3):519-526, doi: 10.3892/ijmm.2017.2877, Epub 2017 Feb 6.

ZhangW, Kong CW, Tong MH, Chooi WH, Huang N, Li RA*, Chan BP, Maturation of Human embryonic stem cell-derivedcardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cellsupplementation and mechanical stimulation, Acta Biomater, 2017Feb;49:204-217, doi: 10.1016/j.actbio.2016.11.058, Epub 2016 Nov 24, PubMedPMID: 27890729, Impact Factor: 6.0

StillitanoF, Hansen J, Kong CW, Karakikes I, Funck-Brentano C, Geng L, Scott S, ReynierS, Wu M, Valogne Y, Desseaux C, Salem JE, Jeziorowska D, Zahr N, Li R*, IyengarR, Hajjar RJ, Hulot JS, Modeling susceptibility to drug-induced long QT with apanel of subject-specific induced pluripotent stem cells, Elife,2017 Jan 30;6, pii: e19406, doi: 10.7554/eLife.19406.

LeeYT, Lin HY, Chan YW, Li KH, To OT, Yan BP, Liu T, Li G, Wong WT, Keung W*, TseG, Mouse models of atherosclerosis: ahistorical perspective and recent advances, Lipids Health Dis, 2017Jan 17;16(1):12, doi: 10.1186/s12944-016-0402-5.

ShumAM, Che H, Wong AO, Zhang C, Wu H, Chan CW, Costa K, Khine M, Kong CW, LiRA*, A Micropatterned Human PluripotentStem Cell-Based Ventricular Cardiac Anisotropic Sheet for VisualizingDrug-Induced Arrhythmogenicity, Adv Mater, 2017 Jan;29(1), doi:10.1002/adma.201602448, Epub 2016 Nov 2.

ChanPK, Li RA*, Gene Delivery for the Generation ofBioartificial Pacemaker, Methods Mol Biol, 2017;1521:293-306.

JunjieLi, Yafei Li, Yuheng Wang, Wendong Ke, Weijian Chen, Weiping Wang*, and ZhishenGe*, Polymer prodrug-based nanoreactorsactivated by tumor acidity for orchestrated oxidation/chemotherapy, NanoLetters, 2017, 17, 6983–6990

AlinaRwei, Juan Paris, Bruce Wang, Weiping Wang, Christopher Axon,Maria Vallet-Regi, Robert Langer and Daniel Kohane*, Ultrasound triggered local anesthesia, NatureBiomedical Engineering, 2017, 1, 644-653 (Highlighted on the journal cover)

TseG, Liu T, Li KH, Laxton V, Chan YW, Keung W, Li RA*, Yan BP, Electrophysiological Mechanisms of Brugada Syndrome:Insights from Pro-clinical and Clinical Studies, Front Physiol, 2016Oct 18;7:467, eCollection 2016, RPubMed PMID: 27803673; PubMed Central PMCID:PMC5067537, doi: 10.3389/fphys.2016.00467

KeungW*, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, LiRA*, Non-cell autonomous cues for enhanced functionality ofhuman embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmaland mitochondrial KATP channels, Sci Rep, 2016 Sep28;6:34154, doi: 10.1038/srep34154.

SohBS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X,Nichane M, Yang H, Bu L, Li RA*, Lim B, Chien KR, Endothelin-1 supports clonal derivation and expansion ofcardiovascular progenitors derived from human embryonic stem cells,Nat Commun, 2016 Mar 8;7:10774, doi: 10.1038/ncomms10774.

ShinSR, Zhang YS, Kim DJ, Manbohi A, Avci H, Silvestri A, Aleman J, Hu N, Kilic T,Keung W*, Righi M, Assawes P, Alhadrami HA, Li RA*, Dokmeci MR, KhademhosseiniA, Aptamer-Based MicrofluidicElectrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers, Anal.Chem., 2016, 88 (20), pp 10019–10027, doi: 10.1021/acs.analchem.6b02028