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[Dr. Li Dak-Sum Research Seminar]

Date: January 21, 2022 (Friday)

Time: 4:00 p.m. – 5:00 p.m. (HKT)

Venue: via ZOOM


**In view of the latest COVID-19 pandemic situation, the seminar will be converted to FULLY VIRTUAL ON ZOOM.**



Biliary Atresia: What do we know and where do we go from here?


by


Dr. Vincent Chi-hang Lui

Associate Professor (by courtesy) in Dr. Li Dak-Sum Research Centre

Associate Professor, Department of Surgery, Li Ka Shing Faculty of Medicine

The University of Hong Kong


Speaker










After obtaining PhD degree from The University of Hong Kong, Dr. Vincent Chi-hang Lui joined the Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands as Postdoctoral Fellow and started his research on embryonic development and developmental disorders. Dr. Lui returned and joined the Department of Surgery, HKU at the end of 1998 as a Research Assistant Professor, promoted to Assistant Professor in 2001, and Associate Professor in 2009.


Dr. Lui is fascinated by embryo development, in particular, how different cells/structures are formed and how does defective development lead to newborn diseases. Using multiple platforms including human and mouse liver/intestinal/lung organoids, iPSCs, single cell and bulk RNA sequencing, Next Generation Sequencing, transgenic and knockout mice, CRISPR/Cas9 gene knockout in zebrafish, human genetics, teratogen induced mouse models of human diseases to identify molecular patho-mechanisms of a number of congenital disorders including Biliary Atresia (BA), Hirschsrung’s Disease (HSCR), Anorectal Malformation Syndrome (ARM), and Congenital Pulmonary Airway Malformation Syndrome (CPAM).


Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns, often diagnosed late, is incurable and frequently requires liver transplantation. The slow progress in the diagnostics/therapeutics area of BA is related to the paucity of knowledge of its underlying patho-mechanisms, ultimate aim of Dr. Lui’s research is to break new grounds in the understanding of BA and enhance its diagnostics and therapy development.


In this talk, Dr. Lui will share with you his findings in the patho-mechanisms of BA, and how these knowledge lead to diagnostic and therapy development.



~~ ALL INTERESTED ARE WELCOME ~~


For enquiries, please contact Ms. Tracy Ching at +852 2831 5375 or tracyhy@hku.hk.


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