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Research Areas

Biomedical Engineering

Publications

Long K, Lv W, Wang Z, Zhang Y, Chen K, Fan N, Li F, Zhang Y, Wang W*. Near-infrared light-triggered prodrug photolysis by one-step energy transfer. Nat Commun. 2023 Dec 7;14(1):8112. doi: 10.1038/s41467-023-43805-y. PMID: 38062051; PMCID: PMC10703928.

Liu J, Zhou Y, Lyu Q, Yao X, Wang W*. Targeted protein delivery based on stimuli-triggered nanomedicine. Exploration 2023, 00, 20230025.

https://doi.org/10.1002/EXP.20230025

Wang T, Zhang Y, Liu Y, Huang Y, Wang W*. Amino Acid-Starved Cancer Cells Utilize

Macropinocytosis and Ubiquitin-Proteasome System for Nutrient Acquisition. Adv Sci (Weinh). 2024 Jan;11(1):e2304791. doi: 10.1002/advs.202304791. Epub 2023 Nov 20. PMID: 37983609; PMCID: PMC10767443.

Liu Y, Xu S, Lyu Q, Huang Y, Wang W*. Ce6 nanoassemblies: molecular mechanism and strategies for combinational anti-cancer therapy. Aggregate 2023, 5, e443. https://doi.org/10.1002/agt2.443.

Xu S, Cui K, Long K, Li J, Fan N, Lam WC, Liang X, Wang W*. Red Light-Triggered Anti-Angiogenic and Photodynamic Combination Therapy of Age-Related Macular Degeneration. Adv Sci (Weinh). 2023 Nov;10(31):e2301985. doi: 10.1002/advs.202301985. Epub 2023 Sep 14. PMID: 37705491; PMCID: PMC10625062.

Chen Y, Huo R, Kang W, Liu Y, Zhao Z, Fu W, Ma R, Zhang X, Tang J, Zhu Z, Lyu Q, Huang Y, Yan M, Jiang B, Chai R, Bao Z, Hu Z, Wang W, Jiang T, Cao Y, Wang J. Tumor-associated monocytes promote mesenchymal transformation through EGFR signaling in glioma. Cell Rep Med. 2023 Sep 19;4(9):101177. doi: 10.1016/j.xcrm.2023.101177. Epub 2023 Aug 30. PMID: 37652019; PMCID: PMC10518634.

Zhang Y, Liu L, Wang T, Mao C, Shan P, Lau CS, Li Z, Guo W, Wang W*. Reactive Oxygen

Species-Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases. Adv Healthc Mater. 2023 Nov;12(29):e2301394. doi:

10.1002/adhm.202301394. Epub 2023 Aug 17. PMID: 37540810.

Zhou Y, Chen K, Lin WK, Liu J, Kang W, Zhang Y, Yang R, Jin L, Cheng Y, Xu A, Wang W*.

Photo-Enhanced Synergistic Induction of Ferroptosis for Anti-Cancer Immunotherapy. Adv Healthc Mater. 2023 Oct;12(27):e2300994. doi: 10.1002/adhm.202300994. Epub 2023 Jul 20. PMID: 37432874.

Wang T, Zhang Y, Chen K, Huang Y, Liu Y, Xu S, Wang W*. CDK4/6 Nano-PROTAC Enhances Mitochondria-dependent Photodynamic Therapy and Anti-tumor Immunity. Nano Today, 2023, 50, 101890, https://doi.org/10.1016/j.nantod.2023.101890.

Kang W, Liu Y, Wang W*. Light-responsive nanomedicine for cancer immunotherapy. Acta Pharm Sin B. 2023 Jun;13(6):2346-2368. doi: 10.1016/j.apsb.2023.05.016. Epub 2023 May 19. PMID: 37425044; PMCID: PMC10326299.

Zhou C, Wu Y, Wang Z, Liu Y, Yu J, Wang W, Chen S, Wu W, Wang J, Qian G, He A. Standardization of organoid culture in cancer research. Cancer Med. 2023 Jul;12(13):14375-14386. doi: 10.1002/cam4.5943. Epub 2023 Apr 20. PMID: 37081739; PMCID: PMC10358246.

Zhang Y, Long K, Wang W*. Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies. J Vis Exp. 2023 Feb 17;(192). doi: 10.3791/64677. PMID: 36876934.

Wang F, Ho P, Kam C, Yang Q, Liu J, Wang W, Zhao E, Chen S. An AIE-active probe for efficient detection and high-throughput identification of outer membrane vesicles. Aggregate, 2023, 4, e312, https://doi.org/10.1002/agt2.312.

Zhou Y, Gao Y, Pang L, Kang W, Man K, Wang W*. A green light-enhanced cytosolic protein delivery platform based on BODIPY-protein interactions. Nano Res. 16, 1042–1051 (2023). https://doi.org/10.1007/s12274-022-4948-4.

Chen K, Cheong LY, Gao Y, Zhang Y, Feng T, Wang Q, Jin L, Honoré E, Lam KSL, Wang W, Hui X, Xu A*. Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects. Nat Commun. 2022 Dec 20;13(1):7838. doi: 10.1038/s41467-022-35470-4. PMID: 36539421; PMCID: PMC9767940.

 

Yuwei Liu, Kaiqi Long, Tianyi Wang, Weirong Kang, Weiping Wang*, Carrier-free nanodrugs for stemness inhibition-enhanced photodynamic therapy, Aggregate, 2022, e284

Lu Liu, Cong Mao, Yuxuan Zhang, Haoting Chen, Yaming Zhang, Jinjin Wang, Chenxing Fu, Xinmiao Lan, Weiping Wang*, Xing-Jie Liang*, Weisheng Guo*, Antibody-sheltered Immunological Nanonut (AINUT) for Rheumatoid Arthritis Targeted Efficient Alleviation, Nano Today, 2022, 47, 101640

Pengfei Shan, Yingwen Lu, Weilin Lu, Xiangping Yin, Haiwei Liu, Daai Li, Xiaoyue Lian, Weiping Wang, Zhongyu Li*, Zhihui Li*, Biodegradable and Lightresponsive Polymeric Nanoparticles for Environmental-safe Herbicide Delivery, ACS Applied Materials & Interfaces, 22022, 14, 38, 43759–43770

Yang Zhou, Yifan Gao, Li Pang, Weirong Kang, Kwan Man, and Weiping Wang*, A green light-enhanced cytosolic protein delivery platform based on BODIPY-protein interactions, Nano Research, 2022, doi: 10.1007/s12274-022-4948-4

Lang Wang, Zhongmin Geng, Yannis Y. L. Ho, Jiayu Zhou, Nicola Judge, Yafei Li, Weiping Wang*, Jinyao Liu*, Yufeng Wang* , Block Co-PolyMOC Micelles and Structural Synergy as Composite Nanocarriers, ACS Applied Materials & Interfaces, 2022, 14, 27, 30546–30556

Yuwei Liu, Kaiqi Long, Weirong Kang, Tianyi Wang, Weiping Wang*, Optochemical control of immune checkpoint blockade via light-triggered PD-L1 dimerization, Advanced NanoBiomed Research, 2022, 2, 6 2200017 (Highlighted on the journal cover)

Kaiqi Long, Yang Yang, Zhanfeng Du, Weirong Kang, Wen Lv, Yafei Li, Yusheng Xie, Hongyan Sung, Changyou Zhan, Weiping Wang*, H2S-responsive Small-Molecule Nanocarrier for Drug Delivery to Colorectal Tumor, Advanced Therapeutics, 2022, 2200044 (Highlighted on the journal cover)

Kathleen Hoi Kei Choy, Sze Yan Chan, William Lam, Jing Jin, Tingting Zheng, Tin Yu Samuel Law, Sidney Siubun Yu, Weiping Wang, Linxian Li, Gangcai Xie, Howard Chi Ho Yim, Hao Chen*, Ellis Kin Lam Fok*, The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis, BMC Biology, 2022, 20, 78

Long K, Wang Y, Lv W, Yang Y, Xu S, Zhan C, Wang W*. Photoresponsive prodrug-dye nanoassembly for in-situ monitorable cancer therapy. Bioengineering & Translational Medicine. 2022 Mar 6; e10311.

Liu J, Kang W, Wang W*. Photocleavage-based photoresponsive drug delivery. Photochem Photobiol. 2022 Mar;98(2):288-302. doi: 10.1111/php.13570. (Invited review)

Wang T, Long K, Zhou Y, Jiang X, Liu J, Fong JHC, Wong ASL, Ng WL, Wang W*. Optochemical Control of mTOR Signaling and mTOR-dependent Autophagy. ACS Pharmacology & Translational Science. 2022 Feb 8;5(3):149-155. doi: 10.1021/acsptsci.1c00230. (Journal cover)

Yang Y, Long K, Wang Y, Li L, Shi J, Liu J, Kong L, Yu L, Ding J, Huang Z*, Wang W*, Zhan C*. NIR light-triggered quantitative pulsed drug release. Adv Healthc Mater. 2021 Dec 1;e2102362. doi: 10.1002/adhm.202102362.

Long K, Han H, Kang W, Lv W, Wang L, Wang Y, Ge L*, Wang W*. One-photon Red Light-triggered Disassembly of Small-molecule Nanoparticles for Drug Delivery. Journal of Nanobiotechnology. 2021 Nov 4;19(1):357. doi: 10.1186/s12951-021-01103-z.

Li Y, Zhou Y, Long K, Zhang Y, Wang T, Wang W*, Photoenhanced cytosolic protein delivery based on a photocleavable group-modified dendrimer. Nanoscale. 2021 Nov 4;13(42):17784-17792. doi: 10.1039/d1nr04430c. (Themed collection: Advanced Functional Nanomaterials for Biomedical Applications)

 

 

Long K, Yang Y, Lv W, Jiang K, Li Y, Lo CY, Lam WC, Zhan C*, Wang W*. Green light-triggered intraocular drug release for intravenous chemotherapy of retinoblastoma. Advanced Science. 2021 Aug 27. doi: 10.1002/advs.202101754.

 

Zhang T, Ma L, Wang L, Xu F, Wei Q, Wang W, Lin Y, Chu Z*. Scalable fabrication of clean nanodiamonds via salt-assisted air oxidation: implications toward sensing and imaging. ACS Applied Nano Materials. 2021 Aug 20;4(9):9223-9230. doi: 10.1021/acsanm.1c01751.

 

Jing M, Li Y, Wang M, Zhang H, Wei P, Zhou Y, Ishimwe N, Huang X, Wang L, Wen L*, Wang W*, Zhang Y*. Photoresponsive PAMAM-assembled nanocarrier loaded with autophagy inhibitor for synergistic cancer therapy. Small. 2021 Aug 8. doi: 10.1002/smll.202102295.

 

Li Y, Lv W, Wang L, Zhang Y, Yang L, Wang T, Zhu L, Wang Y, Wang W*. Photo-triggered nucleus targeting for cancer drug delivery. Nano Research. 2021 Jan 3;14:2630-2636. doi: 10.1007/s12274-020-3264-0.

Wang H, Ding T, Guan J, Liu X, Wang J, Jin P, Hou S, Lu W, Qian J, Wang W, Zhan C*. Interrogation of folic acid functionalized nanomedicines: the regulatory roles of plasma proteins reexamined. ACS Nano. 2020 Oct 21;14(11):14779-14789. doi: 10.1021/acsnano.0c02821.

Lv W, Long K, Yang Y, Chen S, Zhan C, Wang W. A Red Light‐Triggered Drug Release System Based on One‐Photon Upconversion‐Like Photolysis. Adv. Healthcare Mater. 2020 Sep 28. doi: 10.1002/adhm.202001118.

Wang F, Luo R, Xin H, Zhang Y, Wong BJC, Wang W, Lei J. Hypoxia-stimulated tumor therapy associated with the inhibition of cancer cell stemness. Biomaterials. 2020 Sep 10;263:120330. doi: 10.1016/j.biomaterials.2020.120330.

Han H, Li Y, Peng Z, Long K, Zheng C, Wang W, Webster TJ, Ge L. A Soluplus/Poloxamer 407-based self-nanoemulsifying drug delivery system for the weakly basic drug carvedilol to improve its bioavailability. Nanomedicine: Nanotechnology, Biology and Medicine. 2020 Jul;27:102199. doi: 10.1016/j.nano.2020.102199. Epub 2020 Apr 7.

Long K, Liu Y, Li Y, Wang W. Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications. Journal of Materials Chemistry B. 2020 Jul 20;8:6739-6752. doi: 10.1039/d0tb01128b. (Emerging Investigator Themed Collection, Invited review)

Lv W, Wang W*. One-Photon Upconversion-Like Photolysis: A New Strategy to Achieve Long-Wavelength Light-Excitable Photolysis. Synlett. 2020 May 20;31(12):1129-1134. doi: 10.1055/s-0040-1707100. (Synpacts, Invited review)

Lv W, Li Y, Li F, Lan X, Zhang Y, Du L, Zhao Q, Phillips DL, Wang W*. Upconversion-like photolysis of BODIPY-based prodrugs via a one-photon process. Journal of the American Chemical Society. 2019;141(44):17482-17486.

Liu J, Du P, Liu T, Córdova Wong BJ, Wang W, Ju H, Lei J*. A black phosphorus/manganese dioxide nanoplatform: Oxygen self-supply monitoring, photodynamic therapy enhancement and feedback. Biomaterials. 2019;192:179-188.

Wang Z, Zhang Y, Cao B, Ji Z, Luo W, Zhai S, Zhang D, Wang W, Xing D, Hu X*. Explosible Nanocapsules Excited by Pulsed Microwave for Efficient Thermoacoustic-Chemo Combination Therapy. Nanoscale. 2019;11:1710-1719.

Li Y, Zhang Y, Wang W*. Phototriggered targeting of nanocarriers for drug delivery. Nano Research. 2018;11:5424-5438. (Invited Review)

Li J, Li Y, Wang Y, Ke W, Chen W, Wang W*, Ge Z**. Polymer prodrug-based nanoreactors activated by tumor acidity for orchestrated oxidation/chemotherapy. Nano Letters. 2017;17:6983-6990.

Rwei AY, Paris JL, Wang B, Wang W, Axon CD, Vallet-Regí M, Langer R, Kohane DS*. Ultrasound triggered local anesthesia. Nature Biomedical Engineering. 2017;1:644-653. (Highlighted on the journal cover)

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