Research Areas

Neural

Publications

Lau ST, Li Z, Lai FPL, Lui KNC, Li P, Munera JO, Pan G, Mahe MM, Hui CC, Wells JM, Ngan ES. Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses. Gastroenterology. 2019 Dec;157(6):1556-1571.e5. doi: 10.1053/j.gastro.2019.08.019. Epub 2019 Aug 20. PMID: 31442438.

Yin WC, Satkunendran T, Mo R, Morrissy S, Zhang X, Uusküla-Reimand L, Hou H, Huang ES, Liu W, Liu YC, Zhang J, Parker J, Wang X, Farooq H, Selvadurai H, Chen X, Ngan ES, Cheng SY, Dirks PB, Angers S, Wilson MD, Taylor MD, Hui C.C. Dual regulatory functions of SUFU and targetome of GLI2 in SHH medulloblastoma. Dev Cell. 2019;48(2):167-183.e5

Tong M, Che N, Zhou L, Luk ST, Kau PW, Chai S, Ngan ES, Lo CM, Man K, Ding J, Lee TK, Ma S. Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. J Hepatol. 2018 Oct;69(4):826-839.

Tang CS, Li P, Lai FP, Fu AX, Lau ST, So MT, Lui KNC, Li Z, Zhuang X, Yu M, Liu X, Ngo ND, Miao X, Zhang X, Yi B, Tang S, Sun X, Zhang F, Liu H, Liu Q, Zhang R, Wang H, Huang L, Dong, X, Tou J, Cheah KSE, Yang W, Yuan Z, Yip KYL, Sham PC, Tam PKH, Garcia-Barceló MM, Ngan ES*. Identification of Genes Associated with Hirschsprung Disease, Based on Whole-genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development. Gastroenterology. 2018 Sep 11. pii: S0016-5085(18)34965-5.

Lai FP, Lau ST, Wong JW, Gui H, Wang XR, Zhou T, Lai WH, Tse HF, Tam PK, Garcia-Barcelo MM, Ngan ES*. Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function. Gastroenterology. 2017;153(1):139-153.e8

Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome Biology. 2017;18(1):48. doi: 10.1186/s13059-017-1174-6.

Wang XQ, Lo CM, Chen L, Ngan ES, Xu A, Poon RY. CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency. Cell death Differ. 2017;24(1):38-48.

Liu JA, Lai FP, Gui HS, Sham MH, Tam PK, Garcia-Barcelo MM, Hui CC, Ngan ES*. Identification of GLI Mutations in Patients with Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice. Gastroenterology. 2015;149(7):1837-1848.e5. (Highlighted in “Covering the cover” and “Editorials”)

Lau ST, Hansford LM, Chan WK, Chan GC, Wan TS, Wong KK, Kaplan DR, Tam PK, Ngan ES*. Prokineticin signaling is required for the maintenance of a de novo population of c-KIT positive cells to sustain neuroblastoma progression. Oncogene. 2015;34, 1019–1034.